Fresno State's offense, which features standout quarterback Derek Carr and running back Robbie Rouse, grabs the headlines.
But if the Bulldogs win the Mountain West it will be led by a revamped defense.
First-year Fresno State head coach Tim DeRuyter, a successful defensive coordinator at Air Force and Texas A&M, has implemented an aggressive 3-4 front. Oregon stormed out to a 35-6 lead last Saturday but only scored one touchdown in the second half and committed three turnovers in a 42-25 win over the Bulldogs in Eugene.
Colorado starting quarterback Jordan Webb, who has not thrown an interception through two games, knows the Buffs will have to avoid miscues to have a chance on Saturday at Bulldog Stadium.
"Those turnovers are something we're going to have to really focus on, being good about not making the same mistakes," Webb said. "We've been pretty good in that area, we've just got to keep working at it."
The Bulldogs (1-1) are one of seven teams in the nation without a turnover this season. They are tied for eighth nationally in turnover margin (plus-4).
CU is in a three-way tie for ninth in the Pac-12 with a minus-1 turnover margin.
Fresno State had three sacks and 11 tackles for loss against Chip Kelly's explosive Oregon offense.
"Fresno State is fast and really technically sound," said Webb, who has been sacked eight times already. "They're really fundamental in what they do. We have to really pick our spots, take what they give and move down the field."
CU will be without starting center Gus Handler against Fresno State, according to head coach Jon Embree. The junior suffered an ankle injury in the fourth quarter against Sacramento State.
Daniel Munyer, the starting right guard, filled in for Handler. Earlier in the game, Munyer slid over to left guard after starter Alex Lewis was shaken up.
Starting right tackle Jack Harris moved to right guard, and Ryan Dannewitz came off the bench and played right tackle.
Embree said redshirt freshmen Brad Cotner (center) and Stephane Newmbot (tackle) could also be a part of the patchwork unit this Saturday. Offensive line coach Steve Marshall will look closely at the film from Wednesday's practice before setting a starting five.
"We'll just keep plugging," Embree said. "The good news is a lot of those guys played last week and got their feet wet and all that."