Colorado surrendered two early goals and suffered a 2-0 defeat on the road at No. 6 Southern California on Friday night at McAlister Field in Los Angeles.
The loss dropped to CU to 7-5-3 overall and 1-4-1 in the Pac-12, while the USC to 11-1-1 and 5-0-1 with its fifth straight win.
Colorado had a great chance in the second minute when Becca Rasmussen ripped a shot on goal from the top of the box. Her rebound off the save deflected to Megan Massey, but she missed a wide-open net from 10 yards.
USC capitalized just four minutes later when Alex Anthony's one-touch shot with her right foot on a centering pass from the right corner by Tara McKeown deflected off the crossbar and in for a goal.
USC scored again in the 17th minute as Sydney Sladek got in for a breakaway after a through ball from the center of the field by Savannah DeMelo. Sladek finished her shot from the right side of the box to the far post, past a charging Jalen Tompkins.
"You can see some quality in (USC's) movement and we were just too passive in our defending and our shape and they had too much of the ball when we were chasing the game and got down 2-0," Colorado head coach Danny Sanchez said.
Tompkins made six saves for CU , her second-highest total this season. The Buffs were outshot 23-9 and had three shots on goal.
The defending national champion USC is now unbeaten in 10 straight matches and extended its winning streak to five.
CU has now dropped three in a row — all to nationally-ranked teams, including two top-10 opponents.
The Buffs return home for their final homestand of the season. They host Arizona State at 3 p.m. on Thursday and Arizona at 1 p.m. on Sunday, which will be Senior Day.
No. 6 USC 2, Colorado 0Colorado 0 0 — 0
USC 2 0 — 2
Goals (assists) —USC: Alex Anthony (Tara McKeown), fifth minute, Sydney Sladek (Savannah DeMelo), 17th minute.
Goalies (Min-Goals allowed-Saves) — Colorado: Tompkins (90-2-6); USC: Murphy (90-0-3).