No, this isn't another story about the 18-game road losing streak the Buffs will be lugging to the Midwest with them. We're talking about a genuine history-making opportunity here.
The Buffs haven't committed a turnover in their past two games against Cal and Colorado State. The CU record book compiled by sports information guru Dave Plati says the program has never gone three consecutive games without committing a turnover.
"Obviously coach emphasized that right away, and all football coaches do, but they really emphasized it," wide receiver Kyle Cefalo said. "That is something in the past that has really hurt this team, throwing interceptions and fumbling the ball just at the wrong times. It can significantly change games, but as long as the ball is in our hands, we can stay out there.
"They really put it in our head and I think this team really focused on it."
Colorado is tied with eight other programs atop the NCAA rankings for fewest turnovers in the early going this fall.
The only turnover the Buffs have committed came late in the season-opening loss to Hawaii when quarterback Tyler Hansen threw an interception to a defender he never saw.
Hansen has played a big part in the Buffs taking better care of the ball so far.
He came into this season having thrown 17 interceptions and 15 touchdown passes in 20 career games. In three games as a senior, he has thrown seven touchdowns and one interception in 111 passing attempts.
He brings a streak of 81 passes without an interception into Ohio Stadium.
Hansen credited quarterback coach Rip Scherer for helping him understand when and where it is appropriate to take chances with throws and when to throw the ball away or make a play with his feet.
Hansen said he was more likely to throw interceptions earlier in his career because he was still learning to play the position at the college level.
"Part of growing up is learning and taking those chances and making mistakes and learning from them," he said. "I think now I am a smarter player. I know where to go with the ball in certain situations and I think that has helped us out so far."
Colorado coaches are like most in their profession. They use different punishments and motivational tools to encourage players to take care of the football.
Coach Jon Embree said he generally relies on assistant coaches such as offensive coordinator Eric Bieniemy to correct turnover problems.
"Fumbles, that is hammered home cause you've got to protect the football, and I think we've done a pretty good job of that," Embree said.
A split second later, he noted that the CU defense has to do a better job of creating turnovers. CU has take the ball from opponents only three times in three games.
The Buffs face an Ohio State defense that has managed just four takeaways so far this season. But it's also a stingy defense that is allowing only 15 points a game.
The Buckeyes also play with more intensity in front of their home crowd, which usually numbers around 100,000 fans.
Points figure to be at a premium Saturday and taking care of the football will be as important as ever.